전북대학교 생명공학부
전북대학교 생명공학부
생명공학의 미래는 전북대학교 생명공학부가 앞장서겠습니다.

하상훈 교수 (Prof. Sang Hoon Ha)


하상훈 교수
  • MajorBioresource and Biomaterial Technology (생명자원소재전공)
  • Tel063-850-0847
  • Fax063-850-0834
  • Emailsanghoon@jbnu.ac.kr
  • Lab79 Gobong, Iksan, 54596, Republic of Korea (Cellular Systems Biology Lab, Environmental & Bioresource Sciences Building #2, Iksan campus, Chonbuk National University)
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Education

  • 2006. 8Ph.D., Cellular Signal Transduction, POSTECH
  • 2002. 2M.S., Cellular Signal Transduction, POSTECH
  • 1999. 2B.S., Microbiology, Inje University

Professional Experiences

  • 2017. 3 - currentAssistant Professor, Division of Biotechnology, Chonbuk National University
  • 2015. 11 - 2017. 2Research Associate, Department of Chemical and Systems Biology, Stanford University, USA
  • 2010. 1 - 2015. 10Postdoctoral Fellow, Department of Chemical and Systems Biology, Stanford University, USA
  • 2005. 4 - 2009.12Research Scientist, Institute of Molecular Medicine (alternative military service as technical research personnel)
  • 2001. 2 - 2001.6Visiting Scholar, University of Southern Denmark, Denmark
  • 1996. 7 - 1996.9Exchange Student, University of California Davis, USA

Teaching

  • Systems Biology, Synthetic Biology, Cell Biology II, Biotechnology Practice I&II

Research Keywords

  • - Quantitative analysis of systems-level behaviors in biological networks with special emphasis on nutrient signaling, cell cycle regulation, differentiation, cancer development and microbiome
  • - Theory and experimental proof of biological switches for signal amplification and adaptation
  • - Therapeutic intervention of biological bistable systems

Recent Papers Highlighted

  • Ha SH, Ferrell JE Jr (2016) Thresholds and ultrasensitivity from negative cooperativity. Science 352 (6288): 990-993 (IF:37.205)
  • Ha SH, Kim SY, Ferrell JE Jr (2016) The prozone effect accounts for the paradoxical function of the Cdk-binding protein Suc1/Cks. Cell Reports 14 (6): 1408-1421 (IF:8.032)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part III: Cascades, bistable switches, and oscillators. Trends in Biochemical Sciences 39 (12): 612-618 (IF:14.273)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part II: Multisite phosphorylation, stoichiometric inhibitors, and positive feedback. Trends in Biochemical Sciences 39 (11): 556-569 (IF:14.273)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity. Trends in Biochemical Sciences 39 (10): 496-503 (IF:14.273)
  • Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149 (2): 410-24 (IF:31.398)
  • Lee DW, Park KM, Mainak B, Ha SH, Lee T, Suh K, Somak P, Jung H, Kim J, Selvapalam N, Ryu SH, Kim K (2011) Supramolecular fishing for plasma membrane proteins using an ultrastable synthetic host-guest binding pair. Nature Chemistry 3 (2): 154-9 (IF:25.870)

Recent Papers

  • Kim KM*, Hussein UK*, Park SH*, Kang MY, Moon YJ, Zhang Z, Song Y, Park HS, Bae JS, Park BH, Ha SH, Moon WS; Kim JR#, Jang KY# (2019) FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas. Journal of Experimental & Clinical Cancer Research In Press (*: Equal contribution, #: Co-correspondence (IF:6.217)
  • Kim KM†, Hussein UK†, Bae JS†, Park SH, Kwon KS, Ha SH, Park HS, Chung MJ, Moon WS, Kang MJ, Jang KY (2019) The expression patterns of FAM83H and PANX2 are associated with shorter survival of clear cell renal cell carcinoma patients. Frontiers in Oncology 9.14 (†: Equal contribution) (IF:4.416)
  • Bae JS, Noh SJ, Kim KM, Park SH, Hussein UK, Park HS, Park BH, Ha SH, Lee H, Chung MJ, Moon WS, Cho DH, Jang KY (2018) SIRT6 is involved in the progression of ovarian carcinomas via β-catenin-mediated epithelial to mesenchymal transition. Frontiers in Oncology 8. 538 (IF:4.416)
  • Bucher F, Lee J, Shin S, Kim MM, Oh YS, Ha S, Zhang H, Yea K (2018) Interleukin-5 suppresses vascular endothelial growth factor-induced angiogenesis through STAT5 signaling. Cytokine 110. 397-403 (IF:3.488)
  • Park HJ*, Bae JS*, Kim KM, Moon YJ, Park SH, Ha SH, Hussein UK, Zhang Z, Park HS, Moon WS, Kim JR#, Jang KY# (2018) The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma. Journal of Experimental & Clinical Cancer Research 37(1). 107 (*: Equal contribution, #: Co-correspondence) (IF:6.217)
  • Bae JS*, Park JY*, Park SH, Ha SH, An AR, Not SJ, Kwon KS, Jung SH, Kang MJ, Jang KY (2018) Expression of ANO1/DOG1 is associated with shorter survival and progression of breast carcinomas. Oncotarget, 9. 607-621 (*: Equal contribution)
  • Kwon O*, Kwak D*, Ha SH, Jeon H, Park M, Jang Y, Suh PG, Ryu SH (2017) Nudix-type motif 2 (NUDT2) contributes cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 (mTORC1) localization. Cellular Signalling 32, 24-35 (*: Equal contributions) (IF:3.937)
  • Ha SH, Ferrell JE Jr (2016) Thresholds and ultrasensitivity from negative cooperativity. Science 352 (6288): 990-993 (IF:37.205)
  • Ha SH, Kim SY, Ferrell JE Jr (2016) The prozone effect accounts for the paradoxical function of the Cdk-binding protein Suc1/Cks. Cell Reports 14 (6): 1408-1421 (IF:8.032)
  • Oh YS, Bae SS, Park JB, Ha SH, Ryu SH, Suh PG (2015) Mouse sphingosine kinase 1a is negatively regulated through PKC alpha-dependent phosphorylation at S373 residue. PLoS One 10(12): e0143695 (IF:2.766)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part III: Cascades, bistable switches, and oscillators. Trends in Biochemical Sciences 39 (12): 612-618 (IF:14.273)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part II: Multisite phosphorylation, stoichiometric inhibitors, and positive feedback. Trends in Biochemical Sciences 39 (11): 556-569 (IF:14.273)
  • Ferrell JE Jr, Ha SH (2014) Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity. Trends in Biochemical Sciences 39 (10): 496-503 (IF:14.273)
  • Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149 (2): 410-24 (IF:31.398)
  • Lee DW, Park KM, Mainak B, Ha SH, Lee T, Suh K, Somak P, Jung H, Kim J, Selvapalam N, Ryu SH, Kim K (2011) Supramolecular fishing for plasma membrane proteins using an ultrastable synthetic host-guest binding pair. Nature Chemistry 3 (2): 154-9 (IF:25.870)
  • Kim HW, Ha SH, Lee MN, Huston E, Kim DH, Jang SK, Suh PG, Houslay MD, Ryu SH (2010) cAMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology 30 (22): 5406-20 (IF:3.813)
  • Chae YC, Kim KL, Ha SH, Kim J, Suh PG, Ryu SH (2010) PKC delta-mediated phosphorylation of phospholipase D controls integrin mediated cell spreading. Molecular and Cellular Biology 30 (21): 5086-98 (IF:3.813)
  • Kim J, Choi YS, Lim S, Yea K, Yoon JH, Jun DJ, Ha SH, Kim JW, Kim JH, Suh PG, Ryu SH, Lee TG (2010) Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis. Proteomics 10 (3): 394-405 (IF:4.041)
  • Fujii M*, Yi KS*, Kim MJ, Ha SH, Ryu SH, Suh PG**, Yagisawa H** (2009) Phosphorylation of phospholipase C-delta 1 regulates its enzymatic activity. Journal of Cellular Biochemistry 108 (3): 638- 50 (*, **: Equal contributions) (IF:2.959)
  • Chae YC*, Lee S*, Heo K, Ha SH, Jung Y, Kim JH, Ihara Y, Suh PG, Ryu SH (2009) Collapsin response mediator protein-2 regulates neurites formation by modulating tubulin GTPase activity. Cellular Signalling 21 (12): 1818-26 (*: Equal contribution) (IF:3.937)
  • Lee MN, Ha SH, Kim J, Koh A, Lee CS, Kim JH, Jeon H, Kim D-H, Suh PG, Ryu SH (2009) Glycolytic flux signals to mTOR through GAPDH-mediated regulation of Rheb. Molecular and Cellular Biology 29 (14): 3991-4001 (IF:3.813)